Digestive and Liver Disease - Volume 48 - Supplement 2 - February 2016

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Abstracts of the 22nd National Congress of Digestive Diseases / Digestive and Liver Disease 48S2 (2016) e67–e231 e191
height between 1 and 2 mm. 12 lesions with the height of 1 mm
or less were not seen on CT Colonography. 5 lesions are larger than
higher, representing a cancerized lesion.
Concerning the localization of those non polypoid flat lesions, 68/74
lesions were located within right colon. 28 within caecum, 33 within
ascending colon and 7 within transverse colon whilst the remaining
6, 5 were located within rectum and 1 within sigmoid colon.
From the hystological point of view 44/74 lesions were adenoma
with LGD. 21/74 lesions were HDG. 5/74 are flat cancer and 4/74 are
hyperplastic.
Mean reading time using primary 2D approach and 3D as problem
solving was 4’ 28 sec; using CAD has required 52 sec additional
Conclusions: In conclusion, 28% of flat lesion in our population
was missed by radiologists without CAD that improved flat lesion
detection from 70 to 82% of proven lesions. Visualized flat lesions
were 3 mm or lower in height and 6 mm or greater in diameter.
Lesions with a height of 1 mm or less were not seen on CT
colonography.
Also if the use of CAD did not improve mean reading time of the
exam, this softwere could be very helpfull for sourveillance, together
endoscopy, of high risk patients (like those with cancer history or
familiarity for colon cancer, or long history of ulcerative colitis).
P.13.6
A PRIMARY CARE INTERVENTION MODEL ON THE DIVERTICULAR
DISEASE
Campanini A.1, De Conto U.2, Cavasin F.2, Goni E.5, Bastiani F.1,
Canali M.1, Marastoni C.1, Missorini C.1, Ricco’ M.3, Dal Bo’ N.4,
Di Mario F.*5
1Public Health Service, AUSL Parma, Parma, Italy, 2Public Health
Service, AUSL Treviso, Treviso, Italy, 3Dipartimento di Prevenzione,
Unità Operativa di Prevenzione e Sicurezza degli Ambienti di Lavoro,
Azienda Provinciale per i Servizi Sanitari della Provincia Autonoma
di Trento, Trento, Italy, 4Gastroenterological Unit, Treviso Hospital,
Treviso, Italy, 5Department of Clinical and Experimental Medicine,
University of Parma,, Parma, Italy
Background and aim: In routine colonoscopy, diverticulosis is
the most commonly found pathology, a great part of it presents
signs of diverticular disease. The epidemiological data and the
pharmacological approach from the literature do not, exhaustively
reflect, real life and daily practice.
Material and methods: From June 2014 to December 2014 we
enrolled prospectively 178 patients (M/F=0.47, mean age 71.7±11.5
years, min 41-max 95 years) from 15 GPs’ lists, distributed in two
different regions of Northern Italy (Emilia Romagna and Veneto). All
patients symptomatic, diagnosis was confirmed by a colonoscopy.
Patients with acute diverticulitis were excluded.
Based on the predominant symptom patients were addressed to
four different therapeutic approaches:
A) Rifaximin 400 mg b.i.d for 10 days/month;
A1) Rifaximin 400 mg b.i.d for 10 days/month followed by
supplementation with 2 g of Plantago Ovata husk and 24 billions of
different strains of probiotics (a consortium of different species of
Lactobacillus and Bifidobacterium) for 20 days once a day;
B) Mesalamine 800 mg b.i.d for 10 days/month;
B1) Mesalamine 800 mg b.i.d for 10 days/month followed by
supplementation with 3.40 g Plantago ovata husk for 20 days once
a day.
All treatments lasted 3 months.
Statistical analysis was performed blindly from the statistician
by means of univariate analysis (ANOVA + Tukey post-hoc test);
multivariate analysis was performed through a GLM in order to
evaluate the effects of covariates on continuous variables and a
regression analysis for categorical variables.
Results: Sixty-three patients were enrolled in group A, 43 in group
A1, 23 in group B, 31 in group B1.
Eighteen patients dropped out lasting the 3 months of observation
(respectively: 5 in group A, 3 in group A1, 2 in group B and 2 in group
B1). ANOVA suggested a statistically significant difference (p < 0.003)
among groups at T1, with Group A1 and B1 showing higher number
of bowel movement/week. GLM confirmed the role of treatment as
a significant factor (F = 2.858; p = 0.039), associated with BMI (F =
6.972; p < 0.009). Relatively to the bloating, B1 treatment was also
associated with non statistically significant lower levels (p = 0.097;
OR 0.419 95%CI 0.150-1.1710.150-1.171).
Conclusions: In accordance with the baseline clinical presentation,
the supplementation of fiber (Plantago Ovata Husk) and/or 24
billions of different strains of probiotics (in a consortium of different
species of Lactobacillus and Bifidobacterium) are associated with
the statistical significant improvement in the clinical pattern of
symptoms in patients with diverticular disease in primary care /
family physician setting.
P.13.7
CORRELATION BETWEEN GUT PATHOGENS AND FAECAL
LACTOFERRIN LEVELS IN CHILDREN WITH ACUTE DIARRHEA
Warouw S.M.*1, Pangemanan D.H.2, Salendu P.M.1
1Department of Child Health, Faculty of Medicine, Sam Ratulangi
University, Manado, Indonesia, 2Department of Physiology, Faculty of
Medicine, Sam Ratulangi University, Manado, Indonesia
Background and aim: In developing countries, children are
more often exposed to intestinal pathogens, in this case bacteria
that caused acute diarrhea. Difficulties often experienced is the
diagnosis in distinguishing between bacterial and non-bacterial
causes of acute diarrhea. In children for the benefit of antimicrobial
administration, increased level of faecal lactoferrin as a marker of
neutrophil migration in the intestinal lumen and it is associated
with intestinal inflammation.
To analyze the correlation between gut pathogens and faecal
lactoferrin levels in children with acute diarrhea.
Material and methods: An analytic observational with cross
sectional study. This study conducted at general hospital in Manado.
Sampling was conducted consecutively and 43 children suffer
from acute diarrhea, age 7-60 months. The results analyzed with
descriptive analysis for children characteristic and laboratory datas
and also logistic regression analysis. Datas were counted using SPSS
version 21, with levels of significance p<0.05.
Results: This study obtain the relationship between gut pathogens
and faecal lactoferrin levels in children with acute diarrhea
(p<0.0001).
Conclusions: These results suggest that positive intestinal pathogens
in this group of pathologic intestinal bacteria have faecal lactoferrin
levels higher than the negative intestinal pathogens non bacterial.
P.13.8
IRRITABLE BOWEL SYNDROME: EFFECT OF A LOW FODMAP DIET
ON SYMPTOMS AND NUTRIENT INTAKE
Gambarotto P.1, Scapolo P.1, Zulian N.1, D’Odorico A.2, Spinella P.1,
Galeazzi F.*2
1Clinical Nutrition Unit - Padova University Hospital, Padova, Italy,
2UOC Gastroenterologia - Padova University Hospital, Padova, Italy
Background and aim: Background: Patient with irritable bowel
syndrome (IBS) often refer adverse reaction to food, and amelioration
of symptoms after exclusion-diets. Beneficial effects of diets with
reduced intake of substances poorly-incompletely absorbed (such
as fermentable oligosaccharides, disaccharides, monosaccharides